There’s something comically absurd about settling in to watch a Saturday morning soccer match, where fit athletes demonstrate incredible agility, teamwork, and physical excellence on the field, only for the excitement to be interrupted by polished commercials for medications like Jardiance and Apretude. One moment you’re inspired by peak athletic performance and healthy competition, and the next, a calm voiceover is casually mentioning risks of genital gangrene, amputations, or suicidal thoughts. The irony is darkly funny – like watching a fast-food ad during a marathon or a sleep aid commercial at a rock concert. It’s a bizarre juxtaposition that often elicits a chuckle or head shake from viewers. Nevertheless, such products should be allowed to advertise during these games because direct-to-consumer advertising is a legally protected form of commercial speech in the United States, regulated by the FDA which requires a fair balance of benefits and risks. Soccer broadcasts, even Saturday mornings, draw adult audiences including parents and families who can consult their doctors, helping raise awareness about managing diabetes, heart failure, and HIV prevention without evidence of disproportionate harm when information is transparently provided. Restricting these ads would undermine patient empowerment and free-market principles established since the late 1990s.

Jardiance, a medication primarily used to treat type 2 diabetes, heart failure, and chronic kidney disease, carries several serious potential side effects that patients must carefully weigh. These include diabetic ketoacidosis, a life-threatening condition involving dangerously high levels of ketones that can occur even with normal blood sugar levels, leading to symptoms like nausea, vomiting, abdominal pain, and trouble breathing. Other significant risks involve dehydration from increased urination, necrotizing fasciitis of the perineum (a rare but severe genital infection known as Fournier’s gangrene), urinary tract infections, yeast infections in the genital area, low blood sugar when combined with certain other diabetes drugs, and in some cases, lower limb amputations or serious allergic reactions.

Apretude (cabotegravir), an injectable long-acting pre-exposure prophylaxis (PrEP) for reducing the risk of HIV acquisition in at-risk adults and adolescents, also presents notable negative side effects that require strict monitoring. Common issues include injection site reactions such as pain, swelling, and redness, which can persist for days, along with headache, fatigue, fever, diarrhea, and sleep disturbances. More serious risks encompass hypersensitivity reactions that may involve severe rash, fever, muscle aches, blisters, or breathing difficulties; hepatotoxicity or liver damage; and depressive disorders, including depression, suicidal ideation, or attempts. Additionally, it must only be used after confirming HIV-negative status before each dose to avoid drug resistance if infection occurs, and residual drug levels can linger in the body for up to a year or more after stopping.

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